TARGETING ADRENOMEDULLIN IN ONCOLOGY: A FEASIBLE STRATEGY WITH POTENTIAL AS MUCH MORE THAN AN ALTERNATIVE ANTI-ANGIOGENIC THERAPY

The development, maintenance and metastasis of solid tumors are highly dependent on the formation of blood and lymphatic vessels from pre-existing ones through a series of processes that are respectively known as angiogenesis and lymphangiogenesis.Both are mediated by specific growth-stimulating molecules, such as the vascular endothelial growth fa